General Family Information

Serotonin (5-HT) receptors are a family of G protein-coupled receptors (GPCRs) comprised of seven subclasses of receptors: 5-HT1, with five subtypes, 5-HT2, with three subtypes,  5-HT3, 5-HT4, 5-HT5, with two subtypes, 5-HT6, and 5-HT7. Serotonin receptors play a large role in a variety of neurological processes, such as mood, appetite, learning, nausea, sleep, and memory, and are a major target for pharmaceutical and recreational drugs. 5-HT receptor agonists currently have pharmacological utility in treating anxiety, migraines, and constipation, while 5-HT receptor antagonists are used in the treatment of nausea, IBS, and psychotic disorders.

Receptor FamilyReceptorSpeciesParentalStable Cell Lines Division-Arrested Cells Membranes
Serotonin5-HT1AhumanHEK293TC1319DC1319MC1319
5-HT1AhumanHEK293TC1319aDC1319aMC1319a
5-HT1BhumanHEK293TC1320DC1320MC1320
5-HT1BhumanHEK293TC1320aDC1320aMC1320a
5-HT1BhumanHEK293T Gαqi5CG1320DCG1320MCG1320
5-HT2AhumanCHO-K1C1324-1DC1324-1MC1324-1
5-HT2AmouseHEK293TCm1324DCm1324MCm1324
5-HT2AdogHEK293TCd1324DCd1324MCd1324
5-HT2BhumanCHO-K1C1325-1DC1325-1MC1325-1
5-HT2BhumanHEK293TC1325DC1325MC1325
5-HT2BmouseHEK293TCm1325DCm1325MCm1325
5-HT2ChumanCHO-K1C1326-1DC1326-1MC1326-1
5-HT4AhumanCHO-K1C1518-1DC1518-1MC1518-1
5-HT4AmouseCHO-K1Cm1518-1DCm1518-1MCm1518-1
5-HT4BhumanCHO-K1C1330-1DC1330-1MC1330-1
5-HT4BhumanHEK293TC1330DC1330MC1330
5-HT4DhumanCHO-K1C1520-1DC1520-1MC1520-1
5-HT6humanCHO-K1C1331-1DC1331-1MC1331-1
5-HT7humanHEK293TC1334DC1334MC1334