Innovation is in Multispan’s DNA
Dedicated to Advancing Drug Discovery Through Improved High Throughput Screening
Multispan believes innovation is a critical part of driving improvement across the drug discovery and development
pipeline — from promoting a deeper understanding of target biology, to identifying higher quality leads in less time, to
producing more physiologically relevant data for improved clinical translation. Our dedication to innovation is
evidenced through our unique approaches to recombinant expression of membrane proteins and novel assay
technologies which have led to over 30 patents.
MultiScreen™ β-Arrestin Sensor Technology
Multispan recognized the need for improved β-Arrestin screening assays and developed a novel HTS technology, MultiScreen β-Arrestin Sensor technology, that can assess β-Arrestin signaling of native GPCRs in recombinant or primary cells – a critical aspect for assessing receptor physiology.
Our assay kits, reagents and services based on MultiScreen™ β-Arrestin sensor technology enable researchers to examine unmodified GPCRs, including endogenously expressed GPCR targets, which provide more relevant data for
improved identification and optimization of qualified drug candidates.

Don’t let GPCR tagging bias your results. Find out how to unbias your GPCR signaling research.
Accelerated Covid Antiviral And Vaccine Development
Control and eradication of SARS-Cov-2 will require advanced antivirals and/or a protective vaccine – development of both of which depends on improved knowledge of the virus pathophysiology, identification and therapeutic exploitation of the vulnerabilities of the virus, and characterization of the components of protective immunity.
Multispan has a proven record of complex cell engineering and assay development. Ensure the advancement of your SARS-CoV-2 drug and vaccine development efforts by harnessing the knowledge and expertise of their scientific teams. Contact Multispan today to discuss the design and implementation of your COVID assay.

Innovative Expression Technology
Multispan developed a proprietary technology to enable expression of GPCR proteins in mammalian cells at over a
million molecules per cell surface. High expressing cells (HEx™) can be developed into single cell clones and used as a
unique source of high quality GPCR proteins for variety of applications:
- Antibody generation using antigens with natural epitopes at high expression level
- Cell-based or membrane receptor binding assays to achieve high signal-to-noise ratio
- Cell-based functional assays for hard-to-express GPCRs from all 3 structurally distinctive GPCR families
- Structural studies as high-quality source of protein for crystallization
Patents
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Patent No: 10,538,596
CXCR4 binding molecules and methods of use thereof
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Patent No: 10,519,436
Methods and compositions for generation of binding agents against cell surface antigens
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Patent No: 10,434,181
Oligomer-containing benzamide-based compounds
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Patent No: 10,414,771
Compounds useful for inhibiting metastasis from cancer and methods using same
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Patent No: 10,406,202
Therapeutic vitamin D conjugates
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Patent No: 10,336,811
Membrane span-kinase fusion protein and the uses thereof
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Patent No: 10,059,671
Positive allosteric modulators of mGluR3
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Patent No: 9,937,266
Oligomer-containing benzamide-based compounds
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Patent No: 9,908,940
Humanized immunobinders of cell-surface antigens
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Patent No: 9,879,306
Luciferase biosensors for cAMP
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Patent No: 9,879,004
Substituted acetylene derivatives and their use as positive allosteric modulators of mGluR4
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Patent No: 9,856,260
Compounds useful for inhibiting metastasis from cancer and methods using same
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Patent No: 9,763,938
Substituted quinoxalines as positive allosteric modulators of mGluR4
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Patent No: 9,708,321
Spiro-quinazolinone derivatives and their use as positive allosteric modulators of mGluR4
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Patent No: 9,586,999
Methods and compositions related to improving properties of pharmacological agents targeting nervous system
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Patent No: 9,585,934
Therapeutic vitamin D conjugates
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Patent No: 9,375,486
Oligomer-containing benzamide-based compounds
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Patent No: 9,375,474
Compounds useful for inhibiting metastasis from cancer and methods using same
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Patent No: 9,221,905
Methods for producing immunobinders of cell-surface antigens
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Patent No: 9,045,730
Luciferase biosensors for cAMP
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Patent No: 8,962,575
Clerodane derivatives for modulation of leukotriene receptor activity and related diseases
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Patent No: 8,933,020
Methods and compositions related to improving properties of pharmacological agents targeting nervous system
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Patent No: 8,598,374
GPR120 receptor agonists and uses thereof
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Patent No: 8,476,308
GPR120 receptor agonists and uses thereof
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Patent No: 8,465,937
Methods for identifying B-clones which bind cell-surface antigens
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Patent No: 8,435,993
Methods of inhibiting metastasis from cancer
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Patent No: 8,435,940
Methods and compositions related to improving properties of pharmacological agents targeting nervous system
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Patent No: 8,309,600
GPR120 receptor agonists and uses thereof
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Patent No: 8,299,117
GPR120 receptor agonists and uses thereof
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Patent No: 8,227,199
Methods for identifying immunobinders of cell-surface antigens
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Patent No: 8,178,346
GPCR expression vector
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Patent No: 7,781,209
GPCR-expressing cell lines