…from target validation, to HTS screening, compound profiling, lead optimization, and IND lead candidate selection. This applies to programs targeting GPCRs and other families from druggable proteins like kinases, NHRs, transporters, integrins, ion-channels, and more. To expedite drug discovery research, we have built an extensive catalog of MULTISCREEN™ stable cell lines expressing GPCRs, kinases, transporters, integrins, NHRs, and ion channels.
With our uniquely combined assay development and cell sciences expertise, the Multispan team can generate custom stable cell lines that meet your projects’ needs. These custom-generated MULTISCREEN™ stable cell lines are highly characterized single-cell clones, selected and validated in functional assays, and ready to go in high throughput screening and compound profiling. Due to the clonal nature of MULTISCREEN™ stable cell lines, these cell lines guarantee a high performance that will withstand the test of time.
To plan for the secondary counter screens and compound profiling to support hit-to-lead, lead optimization and candidate selection, we will develop secondary HTS screening assays in the primary cells or recombinant MULTISCREENTM stable cell lines for your targets of interest, with additional focuses on: