Peer-Reviewed Papers

Pharmacological profile of upacicalcet, a novel positive allosteric modulator of calcium-sensing receptor, in vitro and in vivo

GPCR Target: Stably human CaSR-expressing HEK-293T

Authors: Moritaka Goto, et al.

Journal: European Journal of Pharmacology, Volume 956, 2023, 175936, ISSN 0014-2999.

Year Published: 2023

Xelaglifam, a novel GPR40/FFAR1 agonist, exhibits enhanced β-arrestin recruitment and sustained glycemic control for type 2 diabetes

GPCR Target: Multiscreen™ TR-FRET cAMP 1.0 No Wash Assay Kit

Authors: Jongmin Yoon, et al.

Journal: Biomedicine & Pharmacotherapy, Volume 177, 2024, 117044, ISSN 0753-3322.

Year Published: 2024

Preclinical development of EXT608, an investigational parathyroid hormone derivative with extended half-life for the treatment of hypoparathyroidism

GPCR Target: PTHR1

Authors: Daniel B. Hall, et al.

Journal: JBMR Plus, Volume 8, Issue 6, June 2024, ziae045.

Year Published: 2024

Structure-Based Drug Design of ADRA2A Antagonists Derived from Yohimbine

GPCR Target: Calcium assay

Authors: Chayka A, et al.

Journal: J Med Chem. 2024 Jun 27;67(12):10135-10151. doi: 10.1021/acs.jmedchem.4c00323.

Year Published: 2024

D-VITylation: Harnessing the biology of vitamin D to improve the pharmacokinetic properties of peptides and small proteins

Authors: Daniel B. Hall, et al.

Company: Pharvaris Netherlands B.V., Leiden, Netherlands

Journal: International Journal of Pharmaceutics, Volume 624, 2022, 122031, ISSN 0378-5173.

Year Published: 2022

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