Peer Reviewed Papers | Multispan, Inc

A novel S1P1 modulator IMMH002 ameliorates psoriasis in multiple animal models

GPCR Target: The transfected Chinese hamster ovary-K1 (CHO-K1) Gaqi5 cells with stable S1P1 expression, hS1P1-CHO,

Authors: Jing Jin, Nina Xue, Yuan Liu, Rong Fu, Mingjin Wang, Ming Ji, Fangfang Lai, Jinping Hu, Xiaojian Wang, Qiong Xiao, Xiaoying Zhang, Dali Yin, Liping Bai, Xiaoguang Chen, Shuan Rao,

Company: State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100050, China; Department of Thoracic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China; State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau SAR China

Journal: Acta Pharmaceutica Sinica B,Volume 10, Issue 2, February 2020,

Predictive models to identify small molecule activators and inhibitors of opioid receptors

GPCR Target: The CHO-K1 cells that express full-length human recombinant μ-, κ-, and δ-OPRs (HMOR, HKOR, and HDOR respectively)

Authors: Srilatha Sakamuru, Jinghua Zhao, Menghang Xia, Huixiao Hong, Anton Simeonov, Iosif Vaisman, and Ruili Huang

Company: Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, Maryland 20850, United States, Bioinformatics and Computational Biology, School of Systems Biology, College of Science, George Mason University, Manassas, Virginia 20110, United States

Journal: Journal of Chemical Information and Modeling 2021 61 (6), 2675-2685

A novel luminescence-based β-arrestin recruitment assay for unmodified receptors

GPCR Target: CHOK1 stable cell lines, the human MOR, KOR, DOR, and NOP were all inserted into the pMEX2 vector from Multispan (puromycin resistant).

Authors: Hauge Pedersen M, Pham J, Mancebo H, Inoue A, Asher WB, Javitch JA.

Company: Departments of Psychiatry & Molecular Pharmacology and Therapeutics, Vagelos College of Physicians & Surgeons, Columbia University, New York, New York, USA; 2 Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, New York, USA; 3 NNF Center for Basic Metabolic Research, Section for Metabolic Receptology, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark; 4 Multispan Inc, Hayward, California, USA; and 5 Department of Pharmacological Sciences, Tohoku University, Sendai, Japan

Journal: J Biol Chem 2022