HUMAN RECOMBINANT 5-HT2C RECEPTOR

MULTISCREEN™ MEMBRANE PREPARATION

Product Information

Catalog Number:
MC1326-1 

Lot Number:
MC1326-1-022422 

Quantity:
8.2mg/mL, 10mg 

Packaging Buffer: 20 mM Gly-Gly, 1 mM MgCl2, 25 mM Sucrose (pH 7.2) 

Host cell:
CHO-K1 

Transfection:
Full-length Human HTR2C cDNA (GenBank Accession Number NM_000868) with FLAG-tag sequence at the N-terminus 

Recommended Storage:
Liquid nitrogen upon receiving; avoid freeze-thaw

Data Sheet

Background: 5-HT2C (5-hydroxytryptamine receptor 2C) is a receptor for serotonin. It is expressed in the brain and spinal cord, especially the choroid plexus. 5-HT2C receptor agonists may have important clinical value in the treatment of mental and eating disorders, such as depression, panic anxiety, OCD, bulimia and obesity. 

Figure 1. Receptor expression on cell surface measured by flow cytometry (FACS) using an anti-FLAG antibody. Black line: parental cells; gray line: receptor-expressing cells. 

References:

Martin et al. (1998) 5-HT2C receptor agonists: Pharmacological characteristics and therapeutic potential. J Pharmacol Exp Ther 286:913-924. 

Ni and Miledi (1997) Blockage of 5HT2C serotonin receptors by fluoxetine (Prozac). Proc Natl Acad Sci USA 94:2036-2040. 

Porter et al. (1999) Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B, and 5-HT2C receptors in CHO-K1 cells. Br J Pharmacol 128:13-20. 

FOR RESEARCH USE ONLY.
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