General Family Information

Chemokine receptors are a very large family of G protein-coupled receptors (GPCRs) that binds the cytokine, chemokine. Chemokine receptors can be broken down into four main subtypes: CXC chemokine receptors, CC chemokine receptors, CX3C chemokine receptors, and XC chemokine receptors, named after the families of chemokines they bind to. Chemokines are a family of proteins responsible for trafficking leukocyte under inflammatory and homeostatic conditions. Certain chemokines also play a role in inhibiting or promoting tumor activity, inhibiting HIV activity, gene expression modulation, and antimicrobial activity. Progress has been made in identifying chemokine receptor antagonists for the treatment of immunologically mediated inflammatory diseases, such as atherosclerosis,  glomerulonephritis, and cardiac graft rejection. A few are currently undergoing clinical trials.

Receptor FamilyReceptorSpeciesParentalStable Cell Lines Division-Arrested Cells Membranes
ChemokineCCR1humanHEK293TC1009DC1009MC1009
CCR1humanHEK293T Gαqi5CG1009DCG1009MCG1009
CCR2humanHEK293TC1010DC1010MC1010
CCR3humanHEK293TC1011DC1011MC1011
CCR3human HEK293T Gαqi5CG1011DCG1011MCG1011
CCR4humanHEK293TC1012DC1012MC1012
CCR4humanHEK293T Gαqi5CG1012DCG1012MCG1012
CCR5humanHEK293TC1013aDC1013aMC1013a
CCR5humanHEK293TC1013bDC1013bMC1013b
CCR5humanHEK293T Gαqi5CG1013DCG1013MCG1013
CCR6humanHEK293TC1014aDC1014aMC1014a
CCR6humanHEK293TC1014bDC1014bMC1014b
CCR6mouseHEK293TCm1014DCm1014MCm1014
CCR7humanHEK293TC1015DC1015MC1015
CCR7humanHEK293T Gαqi5CG1015DCG1015MCG1015
CCR8humanHEK293TC1016DC1016MC1016
CCR8humanHEK293TC1016aDC1016aMC1016a
CCR8humanHEK293T Gαqi5CG1016DCG1016MCG1016
CCR9dogHEK293T Gαqi5CGd1017DCGd1017MCGd1017
CCR9humanHEK293TC1017DC1017MC1017
CCR9humanHEK293TC1017aDC1017aMC1017a
CCR9humanHEK293T Gαqi5CG1017DCG1017MCG1017
CCR9humanHEK293T Gαqi5CG1017ADCG1017AMCG1017A
CCR9mouseHEK293TCm1017DCm1017MCm1017
CCR9mouseHEK293T Gαqi5CGm1017DCGm1017MCGm1017
CCR9ratHEK293T Gαqi5CGr1017DCGr1017MCGr1017
CCR10humanHEK293TC1018DC1018MC1018
CCR10humanCHO-K1 Gαqi5CG1018-1DCG1018-1MCG1018-1
CMKLR1humanHEK293TC1147DC1147MC1147
CMKLR1humanHEK293T Gαqi5CG1147DCG1147MCG1147
CX3CR1humanHEK293TC1008DC1008MC1008
CX3CR1humanHEK293T Gαqi5CG1008aDCG1008aMCG1008a
CX3CR1humanHEK293T Gαqi5CG1008bDCG1008bMCG1008b
CXCR1humanHEK293TC1001aDC1001aMC1001a
CXCR1humanHEK293T Gαqi5CG1001DCG1001MCG1001
CXCR2humanHEK293TC1002DC1002MC1002
CXCR2humanHEK293T Gαqi5CG1002DCG1002MCG1002
CXCR3humanHEK293TC1003DC1003MC1003
CXCR3humanHEK293TC1003aDC1003aMC1003a
CXCR3humanHEK293T Gαqi5CG1003DCG1003MCG1003
CXCR4humanHEK293TC1004-1DC1004-1MC1004-1“>MC1004-1
CXCR4humanHEK293T Gαqi5CG1004DCG1004MCG1004
CXCR5humanHEK293TC1005DC1005MC1005
CXCR5humanHEK293TC1005aDC1005aMC1005a
CXCR5humanCHO-K1C1005-1DC1005-1MC1005-1
CXCR5humanCHO-K1C1005-1aDC1005-1aMC1005-1a
CXCR6humanHEK293TC1006DC1006MC1006
CXCR6humanCHO-K1C1006-1DC1006-1MC1006-1
CXCR6humanHEK293T Gαqi5CG1006DCG1006MCG1006
CXCR7humanHEK293TC1150DC1150MC1150
XCR1humanHEK293TC1007DC1007MC1007