Orphan GPCR Family Subtypes and Products
General Family Information
Orphan receptors are a family of G protein-coupled receptors (GPCRs) comprised of proteins whose endogenous ligands are not known. Once the endogenous ligand is discovered, the receptor is de-orphanized.
| Receptor Family | Receptor | Species | Parental | Stable Cell Lines | Division-Arrested Cells | Membranes |
|---|---|---|---|---|---|---|
| Orphan | GPR3 | human | HEK293T | C1091 | DC1091 | MC1091 |
| GPR6 | human | HEK293T | C1116 | DC1116 | MC1116 | |
| GPR6 | human | HEK293T | C1116a | DC1116a | MC1116a | |
| GPR34 | human | HEK293T Gαqi5 | CG1095 | DCG1095 | MCG1095 | |
| GPR35 | dog | HEK293T Gα16 | CGd1096 | DCGd1096 | MCGd1096 | |
| GPR35 | dog | CHO-K1 Gα16 | CGd1096-1 | DCGd1096-1 | MCGd1096-1 | |
| GPR35 | mouse | CHO-K1 | Cm1096-1 | DCm1096-1 | MCm1096-1 | |
| GPR35 | mouse | CHO-K1 Gα16 | CGm1096-1 | DCGm1096-1 | MCGm1096-1 | |
| GPR35 (short form) | human | CHO-K1 | C1096-1 | DC1096-1 | MC1096-1 | |
| GPR35 (short form) | human | CHO-K1 β-Arrestin2 | CA1096-1 | DCA1096-1 | MCA1096-1 | |
| GPR35 (short form) | human | CHO-K1 Gα16 | CG1096-1 | DCG1096-1 | MCG1096-1 | |
| GPR35 (short form) | human | HEK293T Gα16 | CG1096 | DCG1096 | MCG1096 | |
| GPR35 (long form) | human | CHO-K1 β-Arrestin2 | CA1523-1 | DCA1523-1 | MCA1523-1 | |
| GPR35 (long form) T108M Mutant | human | CHO-K1 β-Arrestin2 | CA1524-1 | DCA1524-1 | MCA1524-1 | |
| GPR37L1 | human | HEK293T | C1098 | DC1098 | MC1098 | |
| GPR45 | human | CHO-K1 | CG1106-1 | DCG1106-1 | MCG1106-1 | |
| GPR45 | human | CHO-K1 | CG1106-1a | DCG1106-1a | MCG1106-1a | |
| GPR50 | human | HEK293T | C1110 | DC1110 | MC1110 | |
| GPR52 | human | HEK293T | C1112 | DC1112 | MC1112 | |
| GPR52 | human | HEK293T | C1112a | DC1112a | MC1112a | |
| GPR52 | human | HEK293T β-Arrestin2 | CA1112BA2 | DCA1112BA2 | MCA1112BA2 | |
| GPR85 | human | HEK293T | C1138 | DC1138 | MC1138 | |
| GPR85 | human | CHO-K1 | C1138-1 | DC1138-1 | MC1138-1 | |
| GPR88 | rat | CHO-K1 | Cr1141-1 | DCr1141-1 | MCr1141-1 | |
| GPR142 | human | HEK293T | C1286 | DC1286 | MC1286 | |
| GPR142 | human | HEK293T | C1286a | DC1286a | MC1286a | |
| GPR151 | human | CHO-K1 Gα16 Gαqi5 | CG1181-1 | DCG1181-1 | MCG1181-1 | |
| GPRC5A | human | HEK293T | CA1525 | DCA1525 | MCA1525 | |
| MRGX1 | human | CHO dhfr-Gαqi5 | C1256 | DC1256 | MC1256 | |
| MRGX2 | human | HEK293T Gαqi5 | C1257 | DC1257 | MC1257 | |
| MRGX2 | human | HEK293T | C1257a | DC1257a | MC1257a | |
| MRGX2 | rhesus monkey | CHO-K1 | Cpr1257-1 | DCpr1257-1 | MCpr1257-1 | |
| MRGX2 | human | HEK293T β-Arrestin2 | CA1257aBA2 | DCA1257aBA2 | MCA1257aBA2 | |
| MAS1 | human | HEK293T | C1225 | DC1225 | MC1225 |