General Family Information

Orphan receptors are a family of G protein-coupled receptors (GPCRs) comprised of proteins whose endogenous ligands are not known. Once the endogenous ligand is discovered, the receptor is de-orphanized.

Receptor FamilyReceptorSpeciesParentalStable Cell Lines Division-Arrested Cells Membranes
OrphanGPR3humanHEK293TC1091DC1091MC1091
GPR34humanHEK293T Gαqi5CG1095DCG1095MCG1095
GPR35dogHEK293T Gα16CGd1096DCGd1096MCGd1096
GPR35dogCHO-K1 Gα16CGd1096-1DCGd1096-1MCGd1096-1
GPR35mouseCHO-K1Cm1096-1DCm1096-1MCm1096-1
GPR35mouseCHO-K1 Gα16CGm1096-1DCGm1096-1MCGm1096-1
GPR35 (short form)humanCHO-K1C1096-1DC1096-1MC1096-1
GPR35 (short form)humanCHO-K1 β-Arrestin2CA1096-1DCA1096-1MCA1096-1
GPR35 (short form)humanCHO-K1 Gα16CG1096-1DCG1096-1MCG1096-1
GPR35 (short form)humanHEK293T Gα16CG1096DCG1096MCG1096
GPR35 (long form)humanCHO-K1 β-Arrestin2CA1523-1DCA1523-1MCA1523-1
GPR35 (long form) T108M MutanthumanCHO-K1 β-Arrestin2CA1524-1DCA1524-1MCA1524-1
GPR37L1humanHEK293TC1098DC1098MC1098
GPR50humanHEK293TC1110DC1110MC1110
GPR85humanHEK293TC1138DC1138MC1138
GPR85humanCHO-K1C1138-1DC1138-1MC1138-1
GPR142humanHEK293TC1286DC1286MC1286
GPR142humanHEK293TC1286aDC1286aMC1286a
GPR151humanCHO-K1 Gα16 Gαqi5CG1181-1DCG1181-1MCG1181-1
MRGX1humanCHO dhfr-Gαqi5C1256DC1256MC1256
MRGX2humanHEK293T Gαqi5C1257DC1257MC1257
MRGX2humanHEK293TC1257aDC1257aMC1257a
MAS1humanHEK293TC1225DC1225MC1225