Lysophospholipid GPCR Family Subtypes and Products

General Family Information

Lysophospholipid receptors are a family of G protein-coupled receptors (GPCRs) comprised of two receptor subtypes: lysophosphatidic acid receptors (LPAs) and sphingosine-1-phosphate receptors (S1Ps). Lysophospholipid receptors are responsible for a variety of cell responses including  angiogenesis, proliferation, migration, mitogenesis, and cytoskeleton changes. LPAs are a target for therapeutic applications in a wide range of disease areas, such as cardiovascular disease, inflammation, cancer, psychiatric disorders, and infertility. S1Ps already have a therapeutic application in the treatment of multiple sclerosis, and research is already being done to develop other S1P modulating drugs.

Receptor FamilyReceptorSpeciesParentalStable Cell Lines Division-Arrested Cells Membranes
LysophospholipidGPR87humanRH7777C1140-6DC1140-6MC1140-6
LPA1humanRH7777C1048-6DC1048-6MC1048-6
LPA1mouseRH7777Cm1048-6ADCm1048-6AMCm1048-6A
LPA1mouseRH7777Cm1048-6BDCm1048-6BMCm1048-6B
LPA1ratRH7777Cr1048-6BDCr1048-6BMCr1048-6B
LPA2humanRH7777C1050-6DC1050-6MC1050-6
LPA3humanRH7777C1053-6DC1053-6MC1053-6
LPA3humanRH7777C1053-6aDC1053-6aMC1053-6a
LPA4humanCHO-K1C1087-1aDC1087-1aMC1087-1a
LPA4humanCHO-K1C1087-1bDC1087-1bMC1087-1b
LPA5humanRH7777C1145-6DC1145-6MC1145-6
LPA5mouseRH7777Cm1145-6DCm1145-6MCm1145-6
S1P1humanCHO-K1C1047-1DC1047-1MC1047-1
S1P1humanCHO-K1 Gαqi5CG1047-1DCG1047-1MCG1047-1
S1P2humanCHO-K1C1051-1DC1051-1MC1051-1
S1P2humanCHO-K1 Gαqi5CG1051-1DCG1051-1MCG1051-1
S1P2mouseCHO-K1Cm1051-1DCm1051-1MCm1051-1
S1P2ratCHO-K1Cr1051-1DCr1051-1MCr1051-1
S1P3humanRH7777C1049-6DC1049-6MC1049-6
S1P3humanCHO-K1C1049-1DC1049-1MC1049-1
S1P3humanCHO-K1 Gαqi5CG1049-1DCG1049-1MCG1049-1
S1P3mouseCHO-K1 Gαqi5CGm1049-1DCGm1049-1MCGm1049-1
S1P3ratCHO-K1 Gαqi5CGr1049-1DCGr1049-1MCGr1049-1
S1P4humanCHO-K1 Gαqi5CG1052-1DCG1052-1MCG1052-1
S1P4mouseCHO-K1 Gαqi5CGm1052-1DCGm1052-1MCGm1052-1
S1P4ratCHO-K1 Gαqi5CGr1052-1DCGr1052-1MCGr1052-1
S1P5humanCHO-K1C1054-1DC1054-1MC1054-1
S1P5humanCHO-K1 Gαqi5CG1054-1DCG1054-1MCG1054-1