Lysophospholipid GPCR Family Subtypes and Products

Lysophospholipid receptors are a family of G protein-coupled receptors (GPCRs) comprised of two receptor subtypes: lysophosphatidic acid receptors (LPAs) and sphingosine-1-phosphate receptors (S1Ps). Lysophospholipid receptors are responsible for a variety of cell responses including  angiogenesis, proliferation, migration, mitogenesis, and cytoskeleton changes. LPAs are a target for therapeutic applications in a wide range of disease areas, such as cardiovascular disease, inflammation, cancer, psychiatric disorders, and infertility. S1Ps already have a therapeutic application in the treatment of multiple sclerosis, and research is already being done to develop other S1P modulating drugs.