Lysophospholipid GPCR Family Subtypes and Products
General Family Information
Lysophospholipid receptors are a family of G protein-coupled receptors (GPCRs) comprised of two receptor subtypes: lysophosphatidic acid receptors (LPAs) and sphingosine-1-phosphate receptors (S1Ps). Lysophospholipid receptors are responsible for a variety of cell responses including angiogenesis, proliferation, migration, mitogenesis, and cytoskeleton changes. LPAs are a target for therapeutic applications in a wide range of disease areas, such as cardiovascular disease, inflammation, cancer, psychiatric disorders, and infertility. S1Ps already have a therapeutic application in the treatment of multiple sclerosis, and research is already being done to develop other S1P modulating drugs.
Receptor Family | Receptor | Species | Parental | Stable Cell Lines | Division-Arrested Cells | Membranes |
---|---|---|---|---|---|---|
Lysophospholipid | GPR87 | human | RH7777 | C1140-6 | DC1140-6 | MC1140-6 |
LPA1 | human | RH7777 | C1048-6 | DC1048-6 | MC1048-6 | |
LPA1 | mouse | RH7777 | Cm1048-6A | DCm1048-6A | MCm1048-6A | |
LPA1 | mouse | RH7777 | Cm1048-6B | DCm1048-6B | MCm1048-6B | |
LPA1 | rat | RH7777 | Cr1048-6B | DCr1048-6B | MCr1048-6B | |
LPA2 | human | RH7777 | C1050-6 | DC1050-6 | MC1050-6 | |
LPA3 | human | RH7777 | C1053-6 | DC1053-6 | MC1053-6 | |
LPA3 | human | RH7777 | C1053-6a | DC1053-6a | MC1053-6a | |
LPA4 | human | CHO-K1 | C1087-1a | DC1087-1a | MC1087-1a | |
LPA4 | human | CHO-K1 | C1087-1b | DC1087-1b | MC1087-1b | |
LPA5 | human | RH7777 | C1145-6 | DC1145-6 | MC1145-6 | |
LPA5 | mouse | RH7777 | Cm1145-6 | DCm1145-6 | MCm1145-6 | |
S1P1 | human | CHO-K1 | C1047-1 | DC1047-1 | MC1047-1 | |
S1P1 | human | CHO-K1 Gαqi5 | CG1047-1 | DCG1047-1 | MCG1047-1 | |
S1P2 | human | CHO-K1 | C1051-1 | DC1051-1 | MC1051-1 | |
S1P2 | human | CHO-K1 Gαqi5 | CG1051-1 | DCG1051-1 | MCG1051-1 | |
S1P2 | mouse | CHO-K1 | Cm1051-1 | DCm1051-1 | MCm1051-1 | |
S1P2 | rat | CHO-K1 | Cr1051-1 | DCr1051-1 | MCr1051-1 | |
S1P3 | human | RH7777 | C1049-6 | DC1049-6 | MC1049-6 | |
S1P3 | human | CHO-K1 | C1049-1 | DC1049-1 | MC1049-1 | |
S1P3 | human | CHO-K1 Gαqi5 | CG1049-1 | DCG1049-1 | MCG1049-1 | |
S1P3 | mouse | CHO-K1 Gαqi5 | CGm1049-1 | DCGm1049-1 | MCGm1049-1 | |
S1P3 | rat | CHO-K1 Gαqi5 | CGr1049-1 | DCGr1049-1 | MCGr1049-1 | |
S1P4 | human | CHO-K1 Gαqi5 | CG1052-1 | DCG1052-1 | MCG1052-1 | |
S1P4 | mouse | CHO-K1 Gαqi5 | CGm1052-1 | DCGm1052-1 | MCGm1052-1 | |
S1P4 | rat | CHO-K1 Gαqi5 | CGr1052-1 | DCGr1052-1 | MCGr1052-1 | |
S1P5 | human | CHO-K1 | C1054-1 | DC1054-1 | MC1054-1 | |
S1P5 | human | CHO-K1 Gαqi5 | CG1054-1 | DCG1054-1 | MCG1054-1 |