HUMAN RECOMBINANT LPA2 (EDG4) RECEPTOR
MULTISCREEN™ MEMBRANE PREPARATION
1 vial (6.1 mg/ml)
Expression vector containing full-length human EDG4 cDNA (GenBank Accession Number NM_004720.4) with FLAG tag sequence at N-terminus
Background: The lysophosphatidic acid receptor LPA2 or endothelial differentiation, G-protein coupled receptor 4(EDG-4) is expressed most abundantly in testes and peripheral blood leukocytes. It is reported to be a distinctive functional marker for ovarian carcinoma.
Figure 1. Receptor expression on cell surface measured by flow cytometry (FACS) using an anti-FLAG antibody. Thin line: parental cells; thick line: receptor- expressing cells.
Huang et al. (2002) Lysophospholipid mediators of immunity and neoplasia. Biochim Biophys Acta 1582:161-167.
An et al. (1998) Characterization of a novel subtype of human G protein coupled receptor for lysophosphatidic acid. J Biol Chem 273:7906-7910.