General Family Information

Glucagon receptors are a family of G protein-coupled receptors (GPCRs) comprised of six receptor subtypes: glucagon, glucagon-like peptide 1 (GLP-1), glucagon-like peptide 2 (GLP-2), gastric inhibitory polypeptide (GIP), growth hormone-releasing hormone (GHRH), and secretin receptors. Glucagon receptors play a major role in the regulation of blood glucose, insulin release, appetite regulation, and other various CNS effects. Glucagon receptor mutations in humans is associated with type II diabetes, hypoglycemia, and islet cell tumors. There are therapeutic applications for glucose receptors in treating diabetes.

Receptor FamilyReceptorSpeciesParentalStable Cell Lines Division-Arrested Cells Membranes
GlucagonGHRHhumanHEK293TC1291DC1291MC1291
GIPhumanHEK293TC1290DC1290MC1290
GIPhumanHEK293T β-Arrestin2CA1290DCA1290MCA1290
GIPmouseHEK293TCm1290DCm1290MCm1290
GIPratHEK293TCr1290DCr1290MCr1290
GIPdogHEK293TCd1290DCd1290MCd1290
GIPdogHEK293TCd1290aDCd1290aMCd1290a
GIPrabbitHEK293TCb1290DCb1290MCb1290
GIPrhesus monkeyHEK293TCpr1290aDCpr1290aMCpr1290a
GIPferretHEK293TCf1290DCf1290MCf1290
GIPferretHEK293TCf1290aDCf1290aMCf1290a
GLP-1humanHEK293TC1267DC1267MC1267
GLP-1humanCHO-K1C1267-1DC1267-1MC1267-1
GLP-1humanCHO-K1C1267-1aDC1267-1aMC1267-1a
GLP-1humanCHO-K1 β-Arrestin2CA1267-1DCA1267-1MCA1267-1
GLP-1cynomolgus monkeyCHO-K1Cpc1267-1DCpc1267-1MCpc1267-1
GLP-1cynomolgus monkeyCHO-K1Cpc1267-1aDCpc1267-1aMCpc1267-1a
GLP-1ratCHO-K1Cr1267-1DCr1267-1MCr1267-1
GLP-1dogCHO-K1Cd1267-1DCd1267-1MCd1267-1
GLP-1mouseCHO-K1Cm1267-1DCm1267-1MCm1267-1
GLP-1mouseCHO-K1Cm1267-1aDCm1267-1aMCm1267-1a
GLP-2humanHEK293TC1268DC1268MC1268
GLP-2ratHEK293TCr1268DCr1268MCr1268
GlucagonhumanHEK293TC1266DC1266MC1266
GlucagonhumanHEK293TC1266ADC1266AMC1266A
GlucagonhumanCHO-K1C1266-1DC1266-1MC1266-1
GlucagonhumanCHO-K1C1266-1aDC1266-1aMC1266-1a
GlucagonhumanCHO-K1 β-Arrestin2CA1266-1DCA1266-1MCA1266-1
Glucagoncynomolgus monkeyCHO-K1Cpc1266-1DCpc1266-1MCpc1266-1
Glucagoncynomolgus monkeyCHO-K1Cpc1266-1aDCpc1266-1aMCpc1266-1a
Glucagoncynomolgus monkeyHEK293TCpc1266DCpc1266MCpc1266
Glucagoncynomolgus monkeyHEK293TCpc1266aDCpc1266aMCpc1266a
SecretinhumanCHO-K1C1228-1DC1228-1MC1228-1