General Family Information

Adrenergic receptors are a family of G protein-coupled receptors (GPCRs) targeted by catecholamines, such as norepinephrine and epinephrine, that consists of two main groups: ɑ receptors and β receptors. ɑ agonists are used to treat rhinitis, and ɑ antagonists can be used to treat pheochromocytoma. β agonists are used in the treatment of heart failure, circulatory shock, or anaphylaxis, while β antagonists can treat conditions such as heart arrhythmia, coronary artery disease, hyperthyroidism, and glaucoma.

Receptor FamilyReceptorSpeciesParentalStable Cell Lines Division-Arrested Cells Membranes
Adrenergicalpha1AhumanCHO-K1C1431-1DC1431-1MC1431-1
alpha1BhumanCHO-K1C1432-1DC1432-1MC1432-1
alpha1DhumanCHO-K1C1433-1DC1433-1MC1433-1
alpha2AhumanCHO-K1C1434-1DC1434-1MC1434-1
alpha2AhumanCHO-K1C1434-1aDC1434-1aMC1434-1a
alpha2BhumanCHO-K1C1435-1DC1435-1MC1435-1
alpha2ChumanCHO-K1C1436-1DC1436-1MC1436-1
beta1humanHEK293TH1437H1437H1437
beta1humanCHO-K1C1437-1DC1437-1MC1437-1
beta2humanCHO-K1C1438-1aDC1438-1aMC1438-1a
beta3humanHEK293TC1439aDC1439aMC1439a