General Family Information

Opioid receptors are a family of G protein-coupled receptors (GPCRs) comprised of five receptor subtypes: delta, kappa, mu, nociceptin receptor, and zeta. Opioid receptors are found all throughout the brain, spinal cord, and digestive tract. They play a major role in a variety of functions including analgesia, anti-depression, anxiety, euphoria, appetite, and sedation. There are currently a large host of clinical drugs that target the mu receptor for its analgesic effects, such as morphine and naloxone.

Receptor FamilyReceptorSpeciesParentalStable Cell Lines Division-Arrested Cells Membranes
OpioiddeltahumanCHO-K1C1351-1DC1351-1MC1351-1
deltahumanCHO-K1 Gαqi5CG1351-1DCG1351-1MCG1351-1
deltahumanCHO-K1CA1351-1DCA1351-1MCA1351-1
deltaratCHO dhfr-C1351DC1351MC1351
kappahumanCHO-K1C1352-1aDC1352-1aMC1352-1a
kappahumanCHO-K1 Gαqi5CG1352-1DCG1352-1MCG1352-1
kappahumanCHO-K1CA1352-1aDCA1352-1aMCA1352-1a
kappahumanHEK293TC1352DC1352MC1352
kapparatCHO dhfr-Cr1352-8DCr1352-8MCr1352-8
muhumanCHO-K1C1350-1aDC1350-1aMC1350-1a
muhumanCHO-K1 Gαqi5CG1350-1aDCG1350-1aMCG1350-1a
muhumanCHO-K1CA1350-1aDCA1350-1aMCA1350-1a
muratCHO dhfr-Cr1350-1aDCr1350-1aMCr1350-1a
mu Mutant Y150FhumanCHO-K1C1350-1MT1DC1350-1MT1MC1350-1MT1
mu Mutant Y150AhumanCHO-K1C1350-1MT2DC1350-1MT2MC1350-1MT2
mu Mutant M153AhumanCHO-K1C1350-1MT3DC1350-1MT3MC1350-1MT3
mu Mutant H299NhumanCHO-K1C1350-1MT4DC1350-1MT4MC1350-1MT4
mu Mutant H299AhumanCHO-K1C1350-1MT5DC1350-1MT5MC1350-1MT5
NOPhumanCHO-K1C1354-1DC1354-1MC1354-1
NOPhumanCHO-K1 Gαqi5CG1354-1DCG1354-1MCG1354-1
NOPhumanCHO-K1 β-Arrestin2CA1354-1DCA1354-1MCA1354-1
NOPhumanHEK293TC1354aDC1354aMC1354a
NOPratCHO dhfr-Cr1354DCr1354MCr1354