General Family Information
Cannabinoid receptors are a class of G protein-coupled receptors (GPCRs) found all throughout the body, and play a large role in mood, memory, pain-sensation and appetite. The cannabinoid receptor family can be broken down into two smaller subtypes of receptors: CB1 and CB2. CB1 receptors are mainly found in the central nervous system, as well as the kidneys, lungs, and liver. CB2 receptors are mainly found in hematopoietic cells and within the immune system. In 2007, however, the GPCR GPR55 was found to bind cannabinoids as well, leading to the discovery of novel cannabinoid receptors. The main component of cannabis, tetrahydrocannabinol (THC), is a cannabinoid receptor agonist used to treat vomiting and lack of appetite in patients with AIDS or cancer.
|Receptor Family||Receptor||Species||Parental||Stable Cell Lines||Division-Arrested Cells||Membranes|
|CB1 MUTANT B||human||CHO-K1 β-Arrestin2||CA1513BA2-1||DCA1513BA2-1||MCA1513BA2-1|