Adrenergic GPCR Family Subtypes and Products
General Family Information
Adrenergic receptors are a family of G protein-coupled receptors (GPCRs) targeted by catecholamines, such as norepinephrine and epinephrine, that consists of two main groups: ɑ receptors and β receptors. ɑ agonists are used to treat rhinitis, and ɑ antagonists can be used to treat pheochromocytoma. β agonists are used in the treatment of heart failure, circulatory shock, or anaphylaxis, while β antagonists can treat conditions such as heart arrhythmia, coronary artery disease, hyperthyroidism, and glaucoma.
Receptor Family | Receptor | Species | Parental | Stable Cell Lines | Division-Arrested Cells | Membranes |
---|---|---|---|---|---|---|
Adrenergic | alpha1A | human | CHO-K1 | C1431-1 | DC1431-1 | MC1431-1 |
alpha1B | human | CHO-K1 | C1432-1 | DC1432-1 | MC1432-1 | |
alpha1D | human | CHO-K1 | C1433-1 | DC1433-1 | MC1433-1 | |
alpha2A | human | CHO-K1 | C1434-1 | DC1434-1 | MC1434-1 | |
alpha2A | human | CHO-K1 | C1434-1a | DC1434-1a | MC1434-1a | |
alpha2B | human | CHO-K1 | C1435-1 | DC1435-1 | MC1435-1 | |
alpha2C | human | CHO-K1 | C1436-1 | DC1436-1 | MC1436-1 | |
beta1 | human | HEK293T | H1437 | H1437 | H1437 | |
beta1 | human | CHO-K1 | C1437-1 | DC1437-1 | MC1437-1 | |
beta2 | human | CHO-K1 | C1438-1a | DC1438-1a | MC1438-1a | |
beta2 | human | HEK293T β-Arrestin1 | CA1438BA1 | DCA1438BA1 | MCA1438BA1 | |
beta2 | human | HEK293T β-Arrestin2 | CA1438BA2 | DCA1438BA2 | MCA1438BA2 | |
beta3 | human | HEK293T | C1439a | DC1439a | MC1439a |