General Family Information

Relaxin receptors are a family of G protein-coupled receptors (GPCRs) comprised of four receptor subtypes: RXFP1, RXFP2, RXFP3, and RXFP4. Through the mediation of relaxin activity, relaxin receptors are involved in a variety of biological processes such as reproduction, anxiety, arousal, and stress response. Relaxin has potential therapeutic application in the treatment of acute heart failure, and is currently undergoing clinical studies. Research is also being done on the application of relaxin in treating asthma, cardiovascular disease, and renal disease.

Receptor FamilyReceptorSpeciesParentalStable Cell Lines Division-Arrested Cells Membranes
RelaxinRXFP1humanHEK293TC1287DC1287MC1287
RXFP1humanHEK293TC1287NTaDC1287NTaMC1287NTa
RXFP1humanHEK293TC1287NTbDC1287NTbMC1287NTb
RXFP2humanHEK293TC1289NTaDC1289NTaMC1289NTa
RXFP2humanHEK293TC1289NTbDC1289NTbMC1289NTb
RXFP3humanHEK293TC1306DC1306MC1306