RECOMBINANT HUMAN RXFP1 RECEPTOR
MULTISCREEN™ MEMBRANE PREPARATION
1 vial (14.78 mg/mL, 5 mg)
20 mM Gly-Gly, 1 mM MgCl2, 25 mM Sucrose (pH 7.2)
Expression vector containing full-length human RXFP1 cDNA (GenBank accession number: NM_021634) with FLAG tag sequence at N-terminus
Store at – 80°C. Avoid repeated freeze-thaw.
Background: The relaxin family peptide receptor RXFP1, also known as LGR7 or RX1, is a 757-amino acid 7 transmembrane protein. RT-PCR detected RXFP1 expression in various organs of the reproductive system along with the brain, heart, and lungs. RXFP1 is known to be important to the connective tissue cells of the breast and play a central role in endometrial deciduation.
Figure 1. Histogram showing receptor expression on cell surface measured by flow cytometry (FACS) using an anti-FLAG antibody. Thin line: parental cells; thick line: receptor-expressing cells.
Ivell et al. (2003) Immunoexpression of the relaxin receptor LGR7 in breast and uterine tissues of humans and primates. Reprod Biol Endocrinol 1:114-114.
Hsu et al. (2002) Activation of orphan receptors by the hormone relaxin. Science 295:671- 674.