Opioid Receptor Family Products GPCR Family Subtypes and Products
General Family Information
Opioid receptors are a family of G protein-coupled receptors (GPCRs) comprised of five receptor subtypes: delta, kappa, mu, nociceptin receptor, and zeta. Opioid receptors are found all throughout the brain, spinal cord, and digestive tract. They play a major role in a variety of functions including analgesia, anti-depression, anxiety, euphoria, appetite, and sedation. There are currently a large host of clinical drugs that target the mu receptor for its analgesic effects, such as morphine and naloxone.
Receptor Family | Receptor | Species | Parental | Stable Cell Lines | Division-Arrested Cells | Membranes |
---|---|---|---|---|---|---|
Opioid | delta | human | CHO-K1 | C1351-1 | DC1351-1 | MC1351-1 |
delta | human | CHO-K1 Gαqi5 | CG1351-1 | DCG1351-1 | MCG1351-1 | |
delta | human | CHO-K1 | CA1351-1 | DCA1351-1 | MCA1351-1 | |
delta | rat | CHO dhfr- | C1351 | DC1351 | MC1351 | |
kappa | human | CHO-K1 | C1352-1a | DC1352-1a | MC1352-1a | |
kappa | human | CHO-K1 Gαqi5 | CG1352-1 | DCG1352-1 | MCG1352-1 | |
kappa | human | CHO-K1 | CA1352-1a | DCA1352-1a | MCA1352-1a | |
kappa | human | CHO-K1 β-Arrestin2 | CA1352BA2-1 | DCA1352BA2-1 | MCA1352BA2-1 | |
kappa | human | HEK293T | C1352 | DC1352 | MC1352 | |
kappa | rat | CHO dhfr- | C1352-1 | DC1352-1 | MC1352-1 | |
kappa | rat | CHO dhfr- | Cr1352-8 | DCr1352-8 | MCr1352-8 | |
mu | human | CHO-K1 | C1350-1a | DC1350-1a | MC1350-1a | |
mu | human | CHO-K1 Gαqi5 | CG1350-1a | DCG1350-1a | MCG1350-1a | |
mu | human | CHO-K1 | CA1350-1a | DCA1350-1a | MCA1350-1a | |
mu | rat | CHO dhfr- | Cr1350-1a | DCr1350-1a | MCr1350-1a | |
mu Mutant Y150F | human | CHO-K1 | C1350-1MT1 | DC1350-1MT1 | MC1350-1MT1 | |
mu Mutant Y150A | human | CHO-K1 | C1350-1MT2 | DC1350-1MT2 | MC1350-1MT2 | |
mu Mutant M153A | human | CHO-K1 | C1350-1MT3 | DC1350-1MT3 | MC1350-1MT3 | |
mu Mutant H299N | human | CHO-K1 | C1350-1MT4 | DC1350-1MT4 | MC1350-1MT4 | |
mu Mutant H299A | human | CHO-K1 | C1350-1MT5 | DC1350-1MT5 | MC1350-1MT5 | |
NOP | human | CHO-K1 | C1354-1 | DC1354-1 | MC1354-1 | |
NOP | human | CHO-K1 Gαqi5 | CG1354-1 | DCG1354-1 | MCG1354-1 | |
NOP | human | CHO-K1 β-Arrestin2 | CA1354-1 | DCA1354-1 | MCA1354-1 | |
NOP | human | HEK293T | C1354a | DC1354a | MC1354a | |
NOP | rat | CHO dhfr- | Cr1354 | DCr1354 | MCr1354 |