General Family Information

Neuropeptide Y receptors are a family of G protein-coupled receptors (GPCRs) comprised of five receptor subtypes: Y1, Y2, Y3, Y4, and Y5; Y3 is not present in humans. The neuropeptide Y receptors play a role in appetite, anxiety, and circadian rhythm. Y1, Y2, Y4, and Y5 are all major drug targets for obesity treatment.

Receptor FamilyReceptorSpeciesParentalStable Cell Lines Division-Arrested Cells Membranes
Neuropeptide YY1humanCHO-K1 Gαqi5CG1273-1DCG1273-1MCG1273-1
Y2humanCHO-K1 Gαqi5CG1274-1DCG1274-1MCG1274-1
Y2ratCHO-K1Cr1274-1DCr1274-1MCr1274-1
Y4humanCHO-K1C1300-1DC1300-1MC1300-1
Y4humanCHO-K1 Gαqi5CG1300-1DCG1300-1MCG1300-1
Y5humanHEK293TC1275aDC1275aMC1275a
Y5humanHEK293T Gαqi5CG1275DCG1275MCG1275