General Family Information

Adenosine receptors are a family of G protein-coupled receptors (GPCRs) that consist of four known receptor subtypes in humans: A1, A2A, A2B and A3. Activation of adenosine receptors with ligand adenosine and agonists and blocking with antagonists enable researchers to study the effects of stimulating and impeding individual adenosine receptor subtypes. The study of adenosine receptors is producing a new generation of compounds that have greater subtype selectivity for a potentially broader field of medical applications.

Receptor FamilyReceptorSpeciesParentalStable Cell LinesDivision-Arrested CellsMembranes
AdenosineA1humanHEK293TC1427BDC1427BMC1427B
A1humanCHO-K1C1427-1DC1427-1MC1427-1
A2AhumanHEK293TC1428DC1428MC1428
A2AhumanCHO-K1C1428-1DC1428-1MC1428-1
A2AmouseHEK293TCm1428ADCm1428AMCm1428A
A2AmouseHEK293TCm1428BDCm1428BMCm1428B
A2AmouseCHO-K1Cm1428-1DCm1428-1MCm1428-1
A2BhumanHEK293TC1429DC1429MC1429
A2BhumanCHO-K1C1429-1DC1429-1MC1429-1
A2BhumanHEK293TC1429aDC1429aMC1429a
A2BratHEK293TCr1429DCr1429MCr1429
A3humanHEK293TC1430DC1430MC1430
A3humanCHO-K1C1430-1DC1430-1MC1430-1