Relaxin GPCR Family Subtypes and Products

What Are Relaxin Receptors?

Relaxin receptors are a family of G protein-coupled receptors (GPCRs) comprised of four receptor subtypes: RXFP1, RXFP2, RXFP3, and RXFP4. Through the mediation of relaxin activity, relaxin receptors are involved in a variety of biological processes such as reproduction, anxiety, arousal, and stress response. Relaxin has potential therapeutic application in the treatment of acute heart failure, and is currently undergoing clinical studies. Research is also being done on the application of relaxin in treating asthma, cardiovascular disease, and renal disease.

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Relaxin Receptor Information

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RXFP1

RXFP2

RXFP3

The relaxin family peptide receptor RXFP1, also known as LGR7 or RX1, is a 757-amino acid 7 transmembrane protein. RT-PCR detected RXFP1 expression in various organs of the reproductive system along with the brain, heart, and lungs. RXFP1 is known to be important to the connective tissue cells of the breast and play a central role in endometrial deciduation.

The relaxin family peptide receptor RXFP2, also known as LGR8, is a 754-amino acid 7 transmembrane protein. RT-PCR detected RXFP2 expression in various organs of the reproductive system along with the brain, kidney, thyroid, muscle, peripheral blood cell, and bone marrow. RXFP2 is known to be important in supporting germ cell function in the testis and ovaries. Additionally, RXFP2 mutations are linked to osteoporosis in men, suggesting that it plays a central role in bone physiology.

The relaxin family peptide receptor RXFP3, also known as GPCR135, RLN3R1 or SALPR, is a 469-amino acid, 7-transmembrane protein. RT-PCR detected RXFP3 expression in various sections of the brain and the testis. RXFP3 is known to be important to several functions of the central nervous system, especially sensory processing under stressful conditions.

Relaxin Cell Lines

Receptor FamilyReceptorSpeciesParentalStable Cell Lines Division-Arrested Cells Membranes
RelaxinRXFP1humanHEK293TC1287DC1287MC1287
RXFP1humanHEK293TC1287NTaDC1287NTaMC1287NTa
RXFP1humanHEK293TC1287NTbDC1287NTbMC1287NTb
RXFP2humanHEK293TC1289NTaDC1289NTaMC1289NTa
RXFP2humanHEK293TC1289NTbDC1289NTbMC1289NTb
RXFP3humanHEK293TC1306DC1306MC1306

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