Neuropeptide Y GPCR Family Subtypes and Products
General Family Information
Neuropeptide Y receptors are a family of G protein-coupled receptors (GPCRs) comprised of five receptor subtypes: Y1, Y2, Y3, Y4, and Y5; Y3 is not present in humans. The neuropeptide Y receptors play a role in appetite, anxiety, and circadian rhythm. Y1, Y2, Y4, and Y5 are all major drug targets for obesity treatment.
| Receptor Family | Receptor | Species | Parental | Stable Cell Lines | Division-Arrested Cells | Membranes |
|---|---|---|---|---|---|---|
| Neuropeptide Y | Y1 | human | CHO-K1 Gαqi5 | CG1273-1 | DCG1273-1 | MCG1273-1 |
| Y2 | human | CHO-K1 Gαqi5 | CG1274-1 | DCG1274-1 | MCG1274-1 | |
| Y2 | rat | CHO-K1 | Cr1274-1 | DCr1274-1 | MCr1274-1 | |
| Y4 | human | CHO-K1 | C1300-1 | DC1300-1 | MC1300-1 | |
| Y4 | human | CHO-K1 Gαqi5 | CG1300-1 | DCG1300-1 | MCG1300-1 | |
| Y5 | human | HEK293T | C1275a | DC1275a | MC1275a | |
| Y5 | human | HEK293T Gαqi5 | CG1275 | DCG1275 | MCG1275 |