General Family Information

Leukotriene receptors are a family of G protein-coupled receptors (GPCRs) comprised of four receptor subtypes: leukotriene B4 receptors (BLTs) and cysteinyl leukotriene receptors (CysLTs), in addition to mediator proteins oxoeicosanoid (OXE) receptor, and formyl peptide receptor 2 (FPR2/ALX). BLT receptors (BLT1 and BLT2) are involved in immunomodulation and chemotaxis, and are vital in understanding the mechanisms behind diseases such as asthma, arthritis, aortic aneurysms, cancer, and sclerosis. CysLT receptors (CysLT1 and CysLT2) are involved in smooth muscle contraction and the regulation of vascular permeability. CysLT antagonists are being used clinically for asthma and allergic rhinitis, and research is being done to determine the therapeutic application of CysLT antagonists for stroke prevention. Research is also being done into the use of OXE receptor antagonists as treatments for cancer and eosinophilic diseases.

Receptor FamilyReceptorSpeciesParentalStable Cell Lines Division-Arrested Cells Membranes
Leukotriene/LipoxinALXhumanHEK293TC1244DC1244MC1244
BLT1humanHEK293TH1165aH1165aH1165a
BLT2humanHEK293TC1272DC1272MC1272
BLT2humanHEK293TC1272ADC1272AMC1272A
BLT2humanHEK293TC1272bDC1272bMC1272b
BLT2humanHEK293TC1272cDC1272cMC1272c
BLT2monkeyHEK293TCp1272aDCp1272aMCp1272a
BLT2monkeyHEK293TCp1272DCp1272MCp1272
BLT2mouseHEK293TCm1272aDCm1272aMCm1272a
BLT2mouseHEK293TCm1272DCm1272MCm1272
CysLT1humanHEK293TC1308DC1308MC1308
CysLT2humanHEK293TC1307DC1307MC1307
OXEhumanHEK293T