General Family Information

Calcitonin receptors are a family of G protein-coupled receptors (GPCRs) generated by the CALCRL and CALCR genes, and contains four subtypes of receptors: calcitonin (CT), calcitonin gene-related peptide (CGRP), adrenomedullin (AM), and amylin (AMY) receptors. In conjunction with receptor activity-modifying proteins (RAMPs), the receptor’s function is changed. The RAMP family is comprised of three members: RAMP1, RAMP2, and RAMP3. Known agonists include ɑ-CGRP, β-CGRP, amylin, adrenemedullin, adrenomedullin 2/intermedin, and calcitonin. Known antagonists include olcegepant and telcagepant.

Receptor FamilyReceptorSpeciesParentalStable Cell Lines Division-Arrested Cells Membranes
CalcitoninCALCRLhumanHEK293TC1232DC1232MC1232
CALCRLhumanCHO-K1C1232-1DC1232-1MC1232-1
CGRPhumanCHO-K1C1515-1DC1515-1MC1515-1
AM1humanCHO-K1C1516-1DC1516-1MC1516-1
AM2humanCHO-K1C1517-1DC1517-1MC1517-1
CThumanHEK293TH1231DH1231MH1231
CThumanCHO-K1C1231-1ADC1231-1AMC1231-1A
CThumanCHO-K1C1231-1BDC1231-1BMC1231-1B
AMY1humanCHO-K1C1509-1aDC1509-1aMC1509-1a
AMY2humanCHO-K1C1510-1aDC1510-1aMC1510-1a
AMY2humanCHO-K1C1510-1bDC1510-1bMC1510-1b
AMY3humanCHO-K1C1511-1aDC1511-1aMC1511-1a