General Family Information

Purinergic receptors are a family of G protein-coupled receptors (GPCRs) found all throughout the body, and are involved in a variety of biological processes, such as vasodilation, blood clotting, and immune system response. Purinergic receptors have wide pharmacological utility, and are currently a large drug target. Established therapeutic uses of purinergic receptors include medication such as clopidogrel, a blood thinner, denufosol, which is used to treat cystic fibrosis, and diquafosol, used for treating dry eye disease. Research is currently being done to determine the potential of P2Y receptors in treating migraines, osteoporosis, diabetes, and heart attacks.

Receptor FamilyReceptorSpeciesParentalStable Cell Lines Division-Arrested Cells Membranes
PurinergicGPR17 (long form)human1321N1C1076-3DC1076-3MC1076-3
GPR17 (long form)human1321N1C1076-3aDC1076-3aMC1076-3a
GPR17 (short form)human1321N1C1526-3DC1526-3MC1526-3
GPR17mouse1321N1Cm1526-3DCm1526-3MCm1526-3
GPR17rat1321N1Cr1526-3DCr1526-3MCr1526-3
P2Y1human1321N1C1160-3DC1160-3MC1160-3
P2Y2human1321N1C1161-3DC1161-3MC1161-3
P2Y2humanHEK293TC1161DC1161MC1161
P2Y2rat1321N1Cr1161-3DCr1161-3MCr1161-3
P2Y4human1321N1C1162-3DC1162-3MC1162-3
P2Y6human1321N1C1164-3DC1164-3MC1164-3
P2Y11human1321N1C1169-3DC1169-3MC1169-3
P2Y12human1321N1C1170-3DC1170-3MC1170-3
P2Y12ratCHO dhfr-C1170-1DC1170-1MC1170-1
P2Y13human1321N1C1139-3DC1139-3MC1139-3
P2Y14humanHEK293TC1057DC1057MC1057
P2Y14humanHEK293T Gαqi5CG1057DCG1057MCG1057
P2Y14ratHEK293T Gαqi5CGr1057DCGr1057MCGr1057
P2Y14monkeyHEK293T Gαqi5CGp1057DCGp1057MCGp1057