General Family Information

Proton-sensing receptors are a family of G protein-coupled receptors (GPCRs) comprised of four receptor subtypes: GPR4, GPR65, GPR68, and GPR132. These receptors are sensitive to extracellular pH levels, and are involved in acid-induced nociceptive pain. Research has also shown a potential role in the regulation of immune system cell proliferation.

Receptor FamilyReceptorSpeciesParentalStable Cell Lines Division-Arrested Cells Membranes
Proton-Sensing ReceptorsGPR4humanHEK293TC1100DC1100MC1100
GPR4humanHEK293TCA1100DCA1100MCA1100
GPR65humanHEK293TC1121DC1121MC1121
GPR65humanHEK293TCA1121DCA1121MCA1121
GPR65humanHEK293TC1121aDC1121aMC1121a
GPR68humanHEK293TC1123DC1123MC1123
GPR68humanHEK293TCA1123DCA1123MCA1123
GPR132humanHEK293TCA1066DCA1066MCA1066