Proton-Sensing GPCR Family Subtypes and Products
General Family Information
Proton-sensing receptors are a family of G protein-coupled receptors (GPCRs) comprised of four receptor subtypes: GPR4, GPR65, GPR68, and GPR132. These receptors are sensitive to extracellular pH levels, and are involved in acid-induced nociceptive pain. Research has also shown a potential role in the regulation of immune system cell proliferation.
Receptor Family | Receptor | Species | Parental | Stable Cell Lines | Division-Arrested Cells | Membranes |
---|---|---|---|---|---|---|
Proton-Sensing Receptors | GPR4 | human | HEK293T | C1100 | DC1100 | MC1100 |
GPR4 | human | HEK293T | CA1100 | DCA1100 | MCA1100 | |
GPR65 | human | HEK293T | C1121 | DC1121 | MC1121 | |
GPR65 | human | HEK293T | CA1121 | DCA1121 | MCA1121 | |
GPR65 | human | HEK293T | C1121a | DC1121a | MC1121a | |
GPR68 | human | HEK293T | C1123 | DC1123 | MC1123 | |
GPR68 | human | HEK293T | CA1123 | DCA1123 | MCA1123 | |
GPR132 | human | HEK293T | CA1066 | DCA1066 | MCA1066 |