Proton-Sensing GPCR Family Subtypes and Products

Proton-sensing receptors are a family of G protein-coupled receptors (GPCRs) comprised of four receptor subtypes: GPR4, GPR65, GPR68, and GPR132. These receptors are sensitive to extracellular pH levels, and are involved in acid-induced nociceptive pain. Research has also shown a potential role in the regulation of immune system cell proliferation.