General Family Information

Prostanoid receptors are a family of G protein-coupled receptors (GPCRs) comprised of 9 receptor subtypes: DP1, DP2, EP1, EP2, EP3, EP4, FP, IP1, and TP receptors. Prostanoid receptors are involved in a wide variety of functions, and agonist and antagonists have been identified for all 9 receptors. DP receptors play a role in sleep regulation and the allergic response, and DP receptor antagonists have shown potential as an anti-inflammatory. EP receptor antagonists have also shown therapeutic potential as anti-inflammatory agents and antagonist activity has been linked to some involvement in atherothrombotic disease. Prostanoid receptor agonists also have therapeutic applications, as FP agonists are already being used as topical treatments for glaucoma, and IP receptor agonists are being used to treat pulmonary hypertension.

Receptor FamilyReceptorSpeciesParentalStable Cell Lines Division-Arrested Cells Membranes
ProstanoidDP1humanHEK293TC1200DC1200MC1200
DP2humanHEK293TH1105DH1105MH1105
DP2humanHEK293TH1105aDH1105aMH1105a
EP1humanHEK293TC1201aDC1201aMC1201a
EP2humanHEK293TC1202DC1202MC1202
EP2mouseHEK293TCm1202DCm1202MCm1202
EP2mouseHEK293TCm1202-3DCm1202-3MCm1202-3
EP2ratHEK293TCr1202DCr1202MCr1202
EP2ratHEK293TCr1202-134DCr1202-134MCr1202-134
EP3humanCHO-K1C1203-1DC1203-1MC1203-1
EP3humanCHO-K1C1203-1aDC1203-1aMC1203-1a
EP3humanCHO-K1C1203-1bDC1203-1bMC1203-1b
EP3humanCHO-K1C1203-1cDC1203-1DCMC1203-1MC
EP3humanCHO-K1C1203-1dDC1203-1dMC1203-1d
EP4humanHEK293TC1204DC1204MC1204
FPhumanHEK293TC1205DC1205MC1205
IP1humanCHO-K1C1206-1DC1206-1MC1206-1
TPhumanHEK293TC1365DC1365MC1365
TPhumanHEK293TH1365H1365H1365