Prostanoid GPCR Family Subtypes and Products

Prostanoid receptors are a family of G protein-coupled receptors (GPCRs) comprised of 9 receptor subtypes: DP1, DP2, EP1, EP2, EP3, EP4, FP, IP1, and TP receptors. Prostanoid receptors are involved in a wide variety of functions, and agonist and antagonists have been identified for all 9 receptors. DP receptors play a role in sleep regulation and the allergic response, and DP receptor antagonists have shown potential as an anti-inflammatory. EP receptor antagonists have also shown therapeutic potential as anti-inflammatory agents and antagonist activity has been linked to some involvement in atherothrombotic disease. Prostanoid receptor agonists also have therapeutic applications, as FP agonists are already being used as topical treatments for glaucoma, and IP receptor agonists are being used to treat pulmonary hypertension.