Small molecule piperazinyl-benzimidazole antagonists of the gonadotropin-releasing hormone (GnRH) receptorGPCR Target: GnRHAuthors: Richard Fjellaksel, et al.Company: UiT The Arctic University of Norway / UNN – University Hospital of North-Norway /…
Genetic Background Can Result in a Marked or Minimal Effect of Gene Knockout (GPR55 and CB2 Receptor) in Experimental Autoimmune Encephalomyelitis Models of Multiple SclerosisGPCR Target: GPR55, CB2Authors: Sofia Sisay,…
20-Iodo-14,15-epoxyeicosa-8(Z)-enoyl-3-azidophenylsulfonamide: Photoaffinity Labeling of a 14,15-Epoxyeicosatrienoic Acid ReceptorGPCR Target: 79-GPCR panelAuthors: Yuenmu Chen, et al.Company: Medical College of Wisconsin / University of Texas Southwestern Medical CenterJournal: Biochemistry 2011, 50, 18,…
In Silico Molecular Comparisons of C. elegans and Mammalian Pharmacology Identify Distinct Targets That Regulate FeedingGPCR Target: Cholescystokinin, Nicotinic AcidAuthors: George A. Lemieux, et al.Company: University of California, San Francisco…
First in vivo evaluation of a potential SPECT brain radiotracer for the gonadotropin releasing hormone receptorGPCR Target: GnRHAuthors: Richard Fjellaksel, et al.Company: UiT The Arctic University of NorwayJournal: BMC Research…
Sphingosine-1-Phosphate Receptor Subtype 1 (S1P1) Modulator IMMH001 Regulates Adjuvant- and Collagen-Induced ArthritisGPCR Target: S1P1Authors: Jing Jin, et al.Company: Chinese Academy of Medical Sciences and Peking Union Medical CollegeJournal: Front. Pharmacol.…
Nucleoside 5′-O-monophosphorothioates as modulators of the P2Y14 receptor and mast cell degranulationGPCR Target: P2Y14Authors: Edyta Gendaszewska-Darmach, et al.Company: Lodz University of Technology / Polish Academy of SciencesJournal: Oncotarget. October 25,…
Pharmacology of AMG 416 (Velcalcetide), a Novel Peptide Agonist of the Calcium-Sensing Receptor, for the Treatment of Secondary Hyperparathyroidism in Hemodialysis PatientsGPCR Target: hCaSRAuthors: Sarah Walter, et al.Company: Amgen, Inc.Journal:…
Amelioration of PXR-mediated CYP3A4 induction by mGluR2 modulatorsGPCR Target: mGLUR2Authors: Roy J.Vaza, et al.Company: Sanofi USJournal: Bioorganic & Medicinal Chemistry Letters Volume 28, Issue 19, October 15, 2018, 3194-3196Year Published: 2018
Discovery of Novel and Potent Leukotriene B4 Receptor Antagonists. Part 1GPCR Target: BLT1/BLT2Authors: Robert A. Goodnow Jr., et al.Company: Roche Research CenterJournal: Journal of Medical Chemistry 2010, 53, 9, 3502-3516Year…