SARS-CoV-2 GPCR Family Subtypes and Products

What Are SARS-CoV-2 Receptors?

“Three coronaviruses have emerged over the last 20 years as serious human pathogens: SARS-CoV was identified as the causative agent in an outbreak in 2002-2003 outbreak, Middle East respiratory syndrome (MERS) CoV emerged in 2012 and the novel coronavirus SARS-CoV-2 emerged in 2019-2020.These are all enveloped, single-stranded positive-sense RNA viruses whose genomes and protein structures are highly conserved” (Alexander SP, Ball JK, Tsoleridis T).

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Alexander SP, Ball JK, Tsoleridis T. Coronavirus (CoV) proteins (version 2020.5) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE. 2020; 2020(5). Available from: https://doi.org/10.2218/gtopdb/F80/2020.5.

SARS-CoV-2 Receptor Information

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ACE2

Angiotensin converting enzyme (ACE2) receptors locate in the human oral pharynx and upper airway where the high replication rate of Corona virus happens more easily. ACE2 has been confirmed as the cause of SARS-CoV-2 internalization in concert with TMPRSS2 (transmembrane protease serin 2). TMPRSS2 facilitates ACEs cell entry by priming the spike S protein of the virus. Therapeutic strategies that focus on the biology of ACE2 and TMPRSS2 may become beneficial for the treatment of lung disease.

SARS-CoV-2 Cell Lines

Receptor Family	Receptor	Species	Parental	Stable Cell Lines	Division-Arrested Cells	Membranes
SARS-CoV-2	ACE2	human	HEK293T	C2006	DC2006	MC2006
SARS-CoV-2	TMPRSS2-ACE2	human	HEK293T	C2007	DC2007	MC2007