Synthesis and characterization of [125I]TZ6544, a promising radioligand for investigating sphingosine-1-phosphate receptor 2GPCR Target: S1PR4 lysophospholipid receptor membraneAuthors: Luo, Z., et al.Journal: Nucl Med Biol. 2020;88-89:52-61. doi:10.1016/j.nucmedbio.2020.07.007Year Published: 2020
The effect of fatty diacid acylation of human PYY3-36 on Y2 receptor potency and half-life in minipigsGPCR Target: CHO cells stably expressing the human Y2R Cat # CG1274Authors: Østergaard, S.,…
Therapeutic antibodies directed at G protein-coupled receptorsGPCR Target: Cell and cell membrane proteinsAuthors: Hutchings, C. J., et al.Journal: mAbs, 2(6), 594–606. https://doi.org/10.4161/mabs.2.6.13420Year Published: 2010
Discovery of CVN636: A Highly Potent, Selective, and CNS Penetrant mGluR7 Allosteric AgonistGPCR Target: mGluR2,6,8 cAMP, mGluR1,3,5 Gαqi5 calcium flux assaysAuthors: Dickson, L., et al.Journal: ACS Medicinal Chemistry Letters 2023…
Discovery of a potent, selective, and tumor-suppressing antibody antagonist of adenosine A2A receptorGPCR Target: MULTISCREEN Division-Arrested HEK293TAuthors: Wang, L., et al.Journal: PLOS ONE 19(6): e0301223. doi.org/10.1371/journal.pone.0301223Year Published: 2024
Retro Drug Design: From Target Properties to Molecular StructuresGPCR Target: hMOR-CHO-K1Authors: Wang, Y., et alJournal: Journal of Chemical Information and Modeling 2022 62 (11), 2659-2669 DOI: 10.1021/acs.jcim.2c00123Year Published: 2022
Field and laboratory perspectives on fentanyl and carfentanil decontaminationGPCR Target: hMOR-CHO-K1-Gαqi5Authors: Lindén, P., et al.Journal: Sci Rep 14, 25381 (2024). doi.org/10.1038/s41598-024-74594-zYear Published: 2024
Discovery of N-substituted-2-oxoindolin benzoylhydrazines as c-MET/SMO modulators in EGFRi-resistant non-small cell lung cancerGPCR Target: HEK293T-WT SMO membranesAuthors: Tomassi S, et al.Journal: RSC Med Chem. 2024;16(1):77-97. doi:10.1039/d4md00553hYear Published: 2024
Palmitic Acid Hydroxystearic Acids Activate GPR40, Which Is Involved in Their Beneficial Effects on Glucose HomeostasisGPCR Target: GPR40 stable cell line, Cyclic AMP AssayAuthors: Syed, I., et al.Journal: Cell Metab.…
Discovery of Novel and Selective GPR17 Antagonists as Pharmacological Tools for Developing New Therapeutic Strategies in Diabetes and ObesityGPCR Target: 1321N1 GPR17 stable cell line (Catalog# Cr1525–3)Authors: Zhu, H., et…