Discovery of CVN636: A Highly Potent, Selective, and CNS Penetrant mGluR7 Allosteric Agonist

GPCR Target: mGluR2,6,8 cAMP, mGluR1,3,5 Gαqi5 calcium flux assays

Authors: Dickson, L., et al.

Journal: ACS Medicinal Chemistry Letters 2023 14 (4), 442-449 DOI: 10.1021/acsmedchemlett.2c00529