I-bodies: human single domain antibodies that antagonize chemokine receptor CXCR4GPCR Target: CXCR4Authors: Katherine Griffithsa, et al.Company: Dept. of Biochemistry, La Trobe University, Australia.Journal: JBC Journal of Biological Chemestry. April 1,…
GPR37 Surface Expression Enhancement via N-Terminal Truncation or Protein-Protein InteractionsGPCR Target: GPR37L1 Authors: Jill H. Dunham, et al.Company: Department of Pharmacology, Emory University School of Medicine, Atlanta, GeorgiaJournal: Biochemistry 2009, 48,…
A novel S1P1 modulator IMMH002 ameliorates psoriasis in multiple animal modelsGPCR Target: S1P1Authors: Jing Jin et al.Company: Institute of Materia Medica, Chinese Academy of Medical SciencesJournal: Acta Pharmaceutica Sinica B…
The N-terminus of GPR37L1 is proteolytically processed by matrix metalloproteasesGPCR Target: GPR37L1Authors: James L. J. Coleman, et al.Company: Molecular Cardiology & Biophysics Division, Victor Chang Cardiac Research Institute, Darlinghurst, AustraliaJournal:…
In Vitro Pharmacological Profile of a New Small Molecule Bradykinin B2 Receptor AntagonistGPCR Target: Calcium assayAuthors: Anne Lesage, et al.Company: Pharvaris Netherlands B.V., Leiden, NetherlandsJournal: Frontiers in Pharmacology. June 19,…
A novel luminescence-based β-arrestin membrane recruitment assay for unmodified GPCRs GPCR Target: μ/κ/d/Nociceptin Authors: Maria Hauge Pedersen, et al. Company: Columbia University, New York Journal: Journal of Biological Chemistry, Volume…
GPR37L1 modulates seizure susceptibility: Evidence from mouse studies and analyses of a human GPR37L1 variantGPCR Target: GPR37L1Authors: Michelle M.Giddensa, et al.Company: Emory University School of Medicine / Children's Mercy HospitalJournal:…
Chapter Two - Potential Use of G Protein-Coupled Receptor-Blocking Monoclonal Antibodies as Therapeutic Agents for CancersAuthor: Deron R.HerrCompany: Expression Drug DesignsJournal: International Review of Cell and Molecular Biology Volume 297,…
Dynarrestin, a Novel Inhibitor of Cytoplasmic DyneinGPCR Target: SMOAuthors: Susanne Höing, et al.Company: Max Planck Institute for Molecular Biomedicine / Lead Discovery Center GmbH / Johns Hopkins University / Technische…
Anticonvulsant Met-Enkephalin Analogues Containing Backbone Spacers Reveal Alternative Non-Opioid Signaling in the BrainGPCR Target: OpioidAuthors: Hee-Kyoung Lee, et al.Company: The University of Utah / The Walter and Eliza Hall Institute…