Cannabinoids for the control of experimental multiple sclerosisAuthors: Gareth PryceCompany: Neuroimmunology Unit, Neuroscience & Trauma Barts and the London School of Medicine and Dentistry Queen Mary University of London UKYear…
Cancer-Associated Mutations Enhance The Sensitivity Of The Trupath GαQ/11 SystemGPCR Target: HEK293T cells overexpressing full-length GIPR or GLP-1R with an N-terminal FLAG tag were purchased from Multispan, IncAuthors: Dewi Safitri,…
New quinolone derivatives as neuropeptide S receptor antagonists: Design, synthesis, homology modeling, dynamic simulations and modulation of Gq/Gs signaling pathways.GPCR Target: Calcium assay, cAMP assayAuthors: Batran RZ, Gugnani KS, Maher…
Distinct biological activities of isomers from several families of branched fatty acid esters of hydroxy fatty acids (FAHFAs). GPCR Target: Calcium assayAuthors: Aryal P, Syed I, Lee J, Patel R, Nelson…
Preferential Gs protein coupling of the galanin Gal1 receptor in the µ-opioid-Gal1 receptor heterotetramerGPCR Target: CHO-K1-Gαqi5 Gal1RAuthors: Paulo A. De Oliveira, Estefanía Moreno, Nil Casajuana-Martin, Verònica Casadó-Anguera, Ning-Sheng Cai, Gisela…
A novel maintenance therapeutic for opioid use disorderGPCR Target: MOR GTPcS assays were conducted at Multispan Inc. (Hayward, CA) in membranes obtained from stably transfected CHO cell expressing the MOR…
In vitro pharmacological profile of PHA-022121, a small molecule bradykinin B2 receptor antagonist in clinical developmentGPCR Target: Antagonist potencies of test items at recombinant dog, rabbit, rat and mouse bradykinin B2 receptors…
A novel S1P1 modulator IMMH002 ameliorates psoriasis in multiple animal modelsGPCR Target: The transfected Chinese hamster ovary-K1 (CHO-K1) Gaqi5 cells with stable S1P1 expression, hS1P1-CHO,Authors: Jing Jin, Nina Xue, Yuan…
Predictive models to identify small molecule activators and inhibitors of opioid receptorsGPCR Target: The CHO-K1 cells that express full-length human recombinant μ-, κ-, and δ-OPRs (HMOR, HKOR, and HDOR respectively)Authors:…
A novel luminescence-based β-arrestin recruitment assay for unmodified receptorsGPCR Target: CHOK1 stable cell lines, the human MOR, KOR, DOR, and NOP were all inserted into the pMEX2 vector from Multispan…