Calcitonin GPCR Family Subtypes and Products

Calcitonin receptors are a family of G protein-coupled receptors (GPCRs) generated by the CALCRL and CALCR genes, and contains four subtypes of receptors: calcitonin (CT), calcitonin gene-related peptide (CGRP), adrenomedullin (AM), and amylin (AMY) receptors. In conjunction with receptor activity-modifying proteins (RAMPs), the receptor’s function is changed. The RAMP family is comprised of three members: RAMP1, RAMP2, and RAMP3. Known agonists include ɑ-CGRP, β-CGRP, amylin, adrenemedullin, adrenomedullin 2/intermedin, and calcitonin. Known antagonists include olcegepant and telcagepant.