Calcitonin GPCR Family Subtypes and Products
General Family Information
Calcitonin receptors are a family of G protein-coupled receptors (GPCRs) generated by the CALCRL and CALCR genes, and contains four subtypes of receptors: calcitonin (CT), calcitonin gene-related peptide (CGRP), adrenomedullin (AM), and amylin (AMY) receptors. In conjunction with receptor activity-modifying proteins (RAMPs), the receptor’s function is changed. The RAMP family is comprised of three members: RAMP1, RAMP2, and RAMP3. Known agonists include ɑ-CGRP, β-CGRP, amylin, adrenemedullin, adrenomedullin 2/intermedin, and calcitonin. Known antagonists include olcegepant and telcagepant.
Receptor Family | Receptor | Species | Parental | Stable Cell Lines | Division-Arrested Cells | Membranes |
---|---|---|---|---|---|---|
Calcitonin | CALCRL | human | HEK293T | C1232 | DC1232 | MC1232 |
CALCRL | human | CHO-K1 | C1232-1 | DC1232-1 | MC1232-1 | |
CGRP | human | CHO-K1 | C1515-1 | DC1515-1 | MC1515-1 | |
AM1 | human | CHO-K1 | C1516-1 | DC1516-1 | MC1516-1 | |
AM2 | human | CHO-K1 | C1517-1 | DC1517-1 | MC1517-1 | |
CT | human | HEK293T | H1231 | DH1231 | MH1231 | |
CT | human | CHO-K1 | C1231-1A | DC1231-1A | MC1231-1A | |
CT | human | CHO-K1 | C1231-1B | DC1231-1B | MC1231-1B | |
AMY1 | human | CHO-K1 | C1509-1 | DC1509-1 | MC1509-1 | |
AMY1 | human | CHO-K1 | C1509-1a | DC1509-1a | MC1509-1a | |
AMY2 | human | CHO-K1 | C1510-1a | DC1510-1a | MC1510-1a | |
AMY2 | human | CHO-K1 | C1510-1b | DC1510-1b | MC1510-1b | |
AMY3 | human | CHO-K1 | C1511-1a | DC1511-1a | MC1511-1a |