General Family Information

Bradykinin receptors are a family of G protein-coupled receptors (GPCRs) consisting of 2 receptors: B1 and B2. The principal ligand, bradykinin is present during conditions such as burns, trauma, allergies, shock, and inflammation. When bound with B1, an acute or chronic inflammatory response is exhibited. B2 antagonist Icatibant has already been approved in the United States and Europe for the treatment of angioedema, and limited trials have been done to assess the validity of Icatibant as an analgesic and anti-inflammatory medication.

Receptor FamilyReceptorSpeciesParentalStable Cell Lines Division-Arrested Cells Membranes
BradykininB1humanHEK293TC1198aDC1198aMC1198a
B1mouseHEK293TCm1198DCm1198MCm1198
B2humanHEK293TH1199DH1199MH1199
B2mouseHEK293TCm1199DCm1199MCm1199
B2ratHEK293TCr1199DCr1199MCr1199
B2dogHEK293TCd1199DCd1199MCd1199
B2rhesus monkeyHEK293TCpr1199DCpr1199MCpr1199
B2guinea pigHEK293TCc1199DCc1199MCc1199
B2rabbitHEK293TCb1199DCb1199MCb1199