Purinergic GPCR Family Subtypes and Products

Purinergic receptors are a family of G protein-coupled receptors (GPCRs) found all throughout the body, and are involved in a variety of biological processes, such as vasodilation, blood clotting, and immune system response. Purinergic receptors have wide pharmacological utility, and are currently a large drug target. Established therapeutic uses of purinergic receptors include medication such as clopidogrel, a blood thinner, denufosol, which is used to treat cystic fibrosis, and diquafosol, used for treating dry eye disease. Research is currently being done to determine the potential of P2Y receptors in treating migraines, osteoporosis, diabetes, and heart attacks.