Neuropeptide W/B GPCR Family Subtypes and Products

What Are Neuropeptide W/B Receptors?

Neuropeptide W/B receptors are a family of G protein-coupled receptors (GPCRs) that bind the endogenous ligands neuropeptides B and W. The two receptors in the family are NPBW1 and NPBW2. These receptors are primarily found within the central nervous system, more specifically the amygdala and hypothalamus. NPB/W receptors play a role in the regulation of food intake, pituitary hormone release, corticosterone release, growth hormone release, and inflammatory pain. Currently, there are no known human NPBW1 or NPBW2 agonists and antagonists.

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Neuropeptide W/B Receptor Information

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NPBW1

NPBW2

Neuropeptide B/neuropeptide W receptor 1 (NPBW1 or GPR7) is a receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals. Targeted disruption of NPBW1 in mice has confirmed that this receptor plays a role in maintaining long-term energy homeostasis. NPBW1 lacking male mice show moderately severe, late-onset obesity that is a result of both hyperphagia and decreased energy expenditure with reduced locomotor activity.

Neuropeptide B/neuropeptide W receptor 2 (NPBW2 or GPR8) is one of the two receptors for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals.

Neuropeptide W/B Cell Lines

Receptor Family	Receptor	Species	Parental	Stable Cell Lines	Division-Arrested Cells	Membranes
Neuropeptide W/B	NPBW1	rat	HEK293T Gαqi5	C1124-1	DC1124-1	MC1124-1
	NPBW1	human	HEK293T Gαqi5	C1124	DC1124	MC1124
	NPBW2	human	HEK293T Gαqi5	C1133	DC1133	MC1133