Neuropeptide W/B GPCR Family Subtypes and Products
General Family Information
Neuropeptide W/B receptors are a family of G protein-coupled receptors (GPCRs) that bind the endogenous ligands neuropeptides B and W. The two receptors in the family are NPBW1 and NPBW2. These receptors are primarily found within the central nervous system, more specifically the amygdala and hypothalamus. NPB/W receptors play a role in the regulation of food intake, pituitary hormone release, corticosterone release, growth hormone release, and inflammatory pain. Currently, there are no known human NPBW1 or NPBW2 agonists and antagonists.