General Family Information

Neuropeptide W/B receptors are a family of G protein-coupled receptors (GPCRs) that bind the endogenous ligands neuropeptides B and W. The two receptors in the family are NPBW1 and NPBW2. These receptors are primarily found within the central nervous system, more specifically the amygdala and hypothalamus. NPB/W receptors play a role in the regulation of food intake, pituitary hormone release, corticosterone release, growth hormone release, and inflammatory pain. Currently, there are no known human NPBW1 or NPBW2 agonists and antagonists.

Receptor FamilyReceptorSpeciesParentalStable Cell Lines Division-Arrested Cells Membranes
Neuropeptide W/BNPBW1ratHEK293T Gαqi5C1124-1DC1124-1MC1124-1
NPBW1humanHEK293T Gαqi5C1124DC1124MC1124
NPBW2humanHEK293T Gαqi5C1133DC1133MC1133