Neuropeptide S GPCR Family Subtypes and Products

What Are Neuropeptide S Receptors?

The neuropeptide S (NPS) receptor is a G protein-coupled receptor (GPCR) found primarily in the central nervous system. Neuropeptide S receptors are involved in many CNS effects, such as arousal and anti-anxiety, and the binding of NPS to NPS receptors also has effects on gastric motility and intestinal permeability. A predisposition to asthma has also been attributed to NPS receptor mutations. Research has also shown a connection between the single-nucleotide polymorphism (SNP) Asn107lle in the NPS receptor to panic disorders, IBS, ADHD, schizophrenia, impulsivity, and sleep.

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Neuropeptide S Receptor Information

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NPS

Neuropeptide S (NPS) receptor 1 is also known as GPR154 or G protein- coupled receptor for asthma susceptibility (GPRA). NPS receptor is widely expressed in the brain, with highest levels found in hypothalamus, amygdala, endopiriform nucleus, cortex, subiculum and nuclei of the thalamic midline. Central administration of NPS promotes behavioral arousal and suppresses all stages of sleep in rodents. Furthermore, NPS was found to produce anxiolytic-like effects in a battery of four different tests that measure behavioral responses of rodents to novelty or stress.

Neuropeptide S Cell Lines

Receptor Family	Receptor	Species	Parental	Stable Cell Lines	Division-Arrested Cells	Membranes
Neuropeptide S	NPS	mouse	HEK293T	C1355-1	DC1355-1	MC1355-1
	NPS	human	HEK293T	C1355a	DC1355a	MC1355a
	NPS(2)	human	HEK293T	C1356	DC1356	MC1356
	NPSIle107	human	HEK293T	C1355-2	DC1355-2	MC1355-2