General Family Information

Muscarinic acetylcholine receptors are a family of G protein-coupled receptors (GPCRs) comprised of five receptor subtypes: M1, M2, M3, M4, and M5. Muscarinic receptors are a major drug target for various human diseases, and plays a large role in a variety of physiological responses. There is therapeutic potential for many muscarinic agonists and antagonists. For example, M1 agonists have therapeutic potential in the treatment of Alzheimer’s, Sjogren’s, and Schizophrenia, while M1 antagonists have potential in treating Parkinson’s. M3 agonists also have potential in the treatment of Type II diabetes, while antagonists have application in treating obesity, peptic ulcers, and IBS.

Receptor FamilyReceptorSpeciesParentalStable Cell Lines Division-Arrested Cells Membranes
MuscarinicM1humanCHO-K1C1022-1DC1022-1MC1022-1
M1humanCHO-K1C1022-1aDC1022-1aMC1022-1a
M2humanCHO-K1C1023-1DC1023-1MC1023-1
M3humanCHO-K1C1024-1DC1024-1MC1024-1
M3mouseCHO-K1Cm1024-1DCm1024-1MCm1024-1
M4humanCHO-K1C1025-1DC1025-1MC1025-1
M4humanCHO-K1 Gαqi5CG1025-1DCG1025-1MCG1025-1
M5humanCHO-K1C1026-1DC1026-1MC1026-1