General Family Information

Histamine receptors are a family of G protein-coupled receptors (GPCRs) comprised of 4 receptors: H1, H2, H3, and H4. Histamine receptors play a large role in the inflammatory process, itching, allergy-related asthma, muscle constriction, and gastric acid secretion. Antihistamines (specific to only H1 receptors) and other histamine receptor antagonists are commonly used as allergy medications and antacids.

Receptor FamilyReceptorSpeciesParentalStable Cell Lines Division-Arrested Cells Membranes
HistamineH1humanHEK293TC1027DC1027MC1027
H1mouseHEK293TCm1027DCm1027MCm1027
H2humanHEK293TC1028DC1028MC1028
H3humanHEK293TC1029DC1029MC1029
H3humanHEK293T Gαqi5CG1029DCG1029MCG1029
H3mouseHEK293TCm1029DCm1029MCm1029
H3 mouseCHO-K1Cm1029-1DCm1029-1MCm1029-1
H4humanHEK293TC1030DC1030MC1030
H4humanHEK293T Gαqi5CG1030DCG1030MCG1030
H4mouseHEK293TCm1030DCm1030MCm1030
H4mouseHEK293T Gαqi5CGm1030DCGm1030MCGm1030