Bradykinin GPCR Family Subtypes and Products

Bradykinin receptors are a family of G protein-coupled receptors (GPCRs) consisting of 2 receptors: B1 and B2. The principal ligand, bradykinin is present during conditions such as burns, trauma, allergies, shock, and inflammation. When bound with B1, an acute or chronic inflammatory response is exhibited. B2 antagonist Icatibant has already been approved in the United States and Europe for the treatment of angioedema, and limited trials have been done to assess the validity of Icatibant as an analgesic and anti-inflammatory medication.