General Family Information

Bile acids are steroid acids synthesized within the liver, making up roughly 80% of the components of bile. The principal bile acids in humans are comprised of two subsets of bile acids, primary and secondary. Primary bile acids include cholic and chenodeoxycholic acid, and secondary bile acids include deoxycholic and lithocholic acid. The primary function of these bile acids is the digestion of fats and oils. G protein-coupled bile acid receptor (GPBA) agonists can help stimulate GLP-1 secretion, aiding in the treatment of obesity and increasing glucose homeostasis.

Receptor FamilyReceptorSpeciesParentalStable Cell Lines Division-Arrested Cells Membranes
Bile AcidGPBAhumanCHO-K1C1361-1DC1361-1MC1361-1
GPBAhumanCHO-K1C1361-1aDC1361-1aMC1361-1a
GPBAratCHO-K1Cr1361-1DCr1361-1MCr1361-1
GPBAmouseCHO-K1Cm1361-1DCm1361-1MCm1361-1
GPBA Mutant W83GhumanCHO-K1C1361-1MT1DC1361-1MT1MC1361-1MT1
GPBA Mutant W83AhumanCHO-K1C1361-1MT2DC1361-1MT2MC1361-1MT2
GPBA Mutant V88LhumanCHO-K1C1361-1MT3DC1361-1MT3MC1361-1MT3
GPBA Mutant Y89AhumanCHO-K1C1361-1MT4DC1361-1MT4MC1361-1MT4
GPBA Mutant Y89HhumanCHO-K1C1361-1MT5DC1361-1MT5MC1361-1MT5
GPBA Mutant F96AhumanCHO-K1C1361-1MT6DC1361-1MT6MC1361-1MT6
GPBA Mutant W237AhumanCHO-K1C1361-1MT7DC1361-1MT7MC1361-1MT7
GPBA Mutant W240AhumanCHO-K1C1361-1MT8DC1361-1MT8MC1361-1MT8