General Family Information

The apelin receptor (APJ), originally designated as an orphan G protein-coupled receptor (GPCR), has the typical 7-transmembrane structure of class A GPCRs, and is comprised of 380 amino acid residues. The receptor has also been found in various other species, such as mouse, rat, cow, and rhesus monkey. APJ plays a role in the regulation of cardiovascular, immunomodulatory, and gastrointestinal function, in addition to fluid homeostasis. APJ has also been discovered to be an HIV co-receptor which, when blocked by apelin peptides, effectively inhibits infection.

Receptor FamilyReceptorSpeciesParentalStable Cell Lines Division-Arrested Cells Membranes
ApelinAPJhumanHEK293TC1196aDC1196aMC1196a
APJhumanCHO-K1C1196-1DC1196-1MC1196-1