General Family Information

Vasopressin and oxytocin receptors are a family of G protein-coupled receptors (GPCRs) found all throughout the brain and peripheral tissue, contributing to a wide range of biological functions. This family is comprised of four receptor subtypes: OT, V1A, V1B, and V2. Peripheral roles for these receptors are more established, such as uterine muscle contraction and the prevention of bodily fluid loss. V2 agonists are used to treat bleeding disorder. In addition, they also play a large role in a variety of social and psychological behaviors, such as attachment, generosity, bonding, and maternal behavior.

Receptor FamilyReceptorSpeciesParentalStable Cell Lines Division-Arrested Cells Membranes
Vasopressin/OxytocinOThumanCHO-K1C1299-1DC1299-1MC1299-1
OTrabbitHEK293TCb1299DCb1299MCb1299
OTrabbitHEK293TCb1299LDCb1299LMCb1299L
V1AhumanCHO-K1C1042-1DC1042-1MC1042-1
V1ArabbitHEK293TCb1042DCb1042MCb1042
V1BhumanCHO-K1C1043-1DC1043-1MC1043-1
V1BrabbitHEK293TCb1043DCb1043MCb1043
V1BrabbitHEK293TCb1043LDCb1043LMCb1043L
V2humanCHO-K1C1044-1DC1044-1MC1044-1
V2rabbitHEK293TCb1044DCb1044MCb1044
V2rabbitHEK293TCb1044LDCb1044LMCb1044L
V2dogCHO-K1Cd1044-1DCd1044-1MCd1044-1