Tools for CXCR7 Characterization, Screening, and Profiling

General Receptor Information

CXCR7 (or ACKR3) is an atypical chemokine receptor (ACKR) that binds with high affinity to the inflammatory and homing chemokines CXCL11/ITAC and CXCL12/SDF-1. CXCR7 is expressed in the bladder, spleen, heart, skeletal muscle, peripheral nervous system and placenta. Similar to other ACKRs, CXCR7 does not activate Gα-mediated signaling. Evidence does suggest that CXCR7/SDF-1α binding stimulates β-arrestin-mediated recruitment and signaling, and that CXCR7 functions beyond acting as a simple decoy to regulate CXCR4/SDF-1α binding.

Read our Scientific Insight: Unraveling CXCR7 Signaling & Therapeutic Potentials

CXCR7 Cells, Membranes & β-arrestin Reagents

Multispan offers a portfolio of high-quality CXCR7 cell line and β-arrestin recruitment assay reagents and kits. Our β-arrestin sensor technology enables CXCR7 “tag-less” monitoring of β-arrestin recruitment.

Multispan cell lines are clonally-derived with rigorous quality control that ensures 99% of the stable cell lines pass 2-month stability. Additionally, all cell lines, including our CXCR7 stable cell line, are fully validated using MultiScreenTM high throughput signaling assays in 384-well format.

Receptor Species Parental Stable Cell Line Division-Arrested Cells Membranes

Don’t see the CXCR7 tool you need? Check out Multispan’s complete service offering including custom cell line generation, high throughput screening & profiling, and cell scale up & banking.

MultiScreen β-Arrestin Recruitment Assays - The Next Generation

MultiScreen β-arrestin assays use translocation of β-arrestin as the assay readout; however, it is β-arrestin and a membrane ‘sensor’ that are tagged rather than the GPCR of interest. Upon recruitment, tagged arrestin comes within proximity of a membrane sensor which in turns results in a functional luciferase enzyme.

This scheme overcomes receptor tagging required by other β-Arrestin assays which can be deleterious, induce receptor conformational changes, lead to steric hinderance, or modify receptor pharmacology – all of which impact the identification and optimization of highly qualified drug candidates.

Ready To Order CXCR7 Cells Or β-Arrestin Reagents?