General Family Information

Somatostatin receptors are a family of G protein-coupled receptors (GPCRs) comprised of five receptor subtypes: SST1, SST2, SST3, SST4, and SST5. These receptors are found all throughout tissue in the brain and peripheral, and are involved in a variety of biological functions such as glucagon secretion, insulin secretion, gastric acid secretion, cell proliferation, angiogenesis, and neuron activity. While more research still needs to be done to discover more subtype-specific agonists and antagonists, somatostatin receptor agonists currently have therapeutic potential in the treatment of neuroendocrine tumours.

Receptor FamilyReceptorSpeciesParentalStable Cell Lines Division-Arrested Cells Membranes
Somatostatinsst1humanCHO-K1C1345-1aDC1345-1aMC1345-1a
sst1humanCHO-K1 Gα16CG1345-1DCG1345-1MCG1345-1
sst2humanCHO-K1C1346-1DC1346-1MC1346-1
sst2humanCHO-K1 Gα16CG1346-1DCG1346-1MCG1346-1
sst3humanCHO-K1C1347-1DC1347-1MC1347-1
sst3humanCHO-K1 Gα16CG1347-1DCG1347-1MCG1347-1
sst4humanCHO-K1C1348-1aDC1348-1aMC1348-1a
sst4humanCHO-K1 Gα16CG1348-1DCG1348-1MCG1348-1
sst5humanCHO-K1C1349-1DC1349-1MC1349-1
sst5humanCHO-K1 Gα16CG1349-1DCG1349-1MCG1349-1